Antibody forming cells in long-term culture of rabbit bone marrow cells.

Abstract

Bone marrow cells from 4 LPS-immunized rabbits were cultured in liquid media for 10 weeks and anti-LPS direct plaque-forming cells were enumerated periodically. Plaque-forming cells decreased for the first 2-4 weeks then increased without addition of LPS. This increase in the number of plaque-forming cells might be ascribed to the differentiation of committed precursors and/or the proliferation of plaque-forming cells.