A Kahan, A Pompidou, P Michel, D Esnous, F Delbarre
{"title":"Lymphocyte nuclear refringence in two inbred strains of rat. Modifications of NRT during adjuvant arthritis.","authors":"A Kahan, A Pompidou, P Michel, D Esnous, F Delbarre","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Nuclear refringence test (NRT) was studied in two inbred strains of rats: Lewis (LEW) and Wistar AG (WAG), the first develops a severe arthritis while the later only slight inflammation. Before adjuvant injection, a good NRT to ConA, PHA and Isoprinosine was observed in LEW but a poor one in WAG. After adjuvant injection a striking difference appears between the two strains concerning ConA response: in LEW the response is significantly lower on day 14, while in WAG the initial poor response is not modified. These data suggest that in WAG the suppressor T lymphocytes are already activated in vivo and are no longer responsive in vitro. The responses to PHA and Isoprinosine are parallel in both strains, the NRT response diminishes on day 14 in LEW and on day 21 in WAG.</p>","PeriodicalId":9217,"journal":{"name":"Biomedicine / [publiee pour l'A.A.I.C.I.G.]","volume":"35 7-8","pages":"212-4"},"PeriodicalIF":0.0000,"publicationDate":"1981-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomedicine / [publiee pour l'A.A.I.C.I.G.]","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Nuclear refringence test (NRT) was studied in two inbred strains of rats: Lewis (LEW) and Wistar AG (WAG), the first develops a severe arthritis while the later only slight inflammation. Before adjuvant injection, a good NRT to ConA, PHA and Isoprinosine was observed in LEW but a poor one in WAG. After adjuvant injection a striking difference appears between the two strains concerning ConA response: in LEW the response is significantly lower on day 14, while in WAG the initial poor response is not modified. These data suggest that in WAG the suppressor T lymphocytes are already activated in vivo and are no longer responsive in vitro. The responses to PHA and Isoprinosine are parallel in both strains, the NRT response diminishes on day 14 in LEW and on day 21 in WAG.
对Lewis (LEW)和Wistar AG (WAG)两种近交系大鼠进行了核折射试验(NRT)，前者表现为严重的关节炎，后者仅表现为轻微的炎症。佐剂注射前，LEW对ConA、PHA和异丙氨酸的NRT良好，而WAG的NRT较差。注射佐剂后，两株在ConA反应方面出现了显著差异:LEW在第14天的反应明显降低，而WAG最初的不良反应没有得到改善。这些数据表明，在WAG中，抑制T淋巴细胞在体内已经被激活，并且在体外不再有反应。两种菌株对PHA和异丙氨酸的反应是平行的，LEW的NRT反应在第14天减弱，WAG在第21天减弱。
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