{"title":"Comparison between dissociation and inhibition of association of DNA/anti-DNA complexes.","authors":"R J Smeenk, L A Aarden, C J van Oss","doi":"10.3109/08820138309066867","DOIUrl":null,"url":null,"abstract":"<p><p>A study was made of the increases in ionic strength (mu) and in pH that would effect: a) the inhibition of association of anti-double stranded (ds) DNA and dsDNA, and b) the dissociation of anti-dsDNA from dsDNA, with respect to high avidity as well as to low avidity human anti-dsDNA antibodies, using Crithidia luciliae kinetoplasts as a source of dsDNA. The results obtained appear to indicate that the electrostatic component of the antigen-antibody bond does not become stronger with time (for times spans less than 1 hr).</p>","PeriodicalId":13417,"journal":{"name":"Immunological communications","volume":"12 2","pages":"177-88"},"PeriodicalIF":0.0000,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/08820138309066867","citationCount":"27","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Immunological communications","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3109/08820138309066867","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 27
Abstract
A study was made of the increases in ionic strength (mu) and in pH that would effect: a) the inhibition of association of anti-double stranded (ds) DNA and dsDNA, and b) the dissociation of anti-dsDNA from dsDNA, with respect to high avidity as well as to low avidity human anti-dsDNA antibodies, using Crithidia luciliae kinetoplasts as a source of dsDNA. The results obtained appear to indicate that the electrostatic component of the antigen-antibody bond does not become stronger with time (for times spans less than 1 hr).
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