A study of clinico-histologic correlation in lesions of borderline leprosy with multiple skin biopsies from different sites.

Abstract

20 active untreated cases of borderline leprosy were subdivided on clinical, bacteriological and immunological grounds. None had reactional episodes. Multiple skin biopsies from each one of them showed varied histopathology from different lesions. 84 out of 93 biopsies (90.3%) were found not to be in agreement with the clinical diagnosis. Even the multiple biopsies obtained from single large lesion revealed varied histopathological picture. The reason for the histopathological disparity has been postulated.