T Sakano, A Hosokawa, N Horino, S Hyodo, T Kishi, T Suzawa, E Kittaka, N Sakura, T Usui
{"title":"A case of immunodeficiency with decreased serum IgA levels and impaired polyclonal B cell differentiation in vitro.","authors":"T Sakano, A Hosokawa, N Horino, S Hyodo, T Kishi, T Suzawa, E Kittaka, N Sakura, T Usui","doi":"10.1111/j.1651-2227.1983.tb09818.x","DOIUrl":null,"url":null,"abstract":"<p><p>We report a patient with low serum IgA levels and persistent pulmonary infection. In spite of the normal contents of serum IgG and IgM, the patient had a deficiency for plasma cell differentiation of all major classes of immunoglobulins (IgG, IgA and IgM). Cross culture systems between normal T or B cells and the patient's T or B cells showed a defect of both T and B cell function.</p>","PeriodicalId":75407,"journal":{"name":"Acta paediatrica Scandinavica","volume":"72 5","pages":"797-9"},"PeriodicalIF":0.0000,"publicationDate":"1983-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1651-2227.1983.tb09818.x","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta paediatrica Scandinavica","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1111/j.1651-2227.1983.tb09818.x","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
We report a patient with low serum IgA levels and persistent pulmonary infection. In spite of the normal contents of serum IgG and IgM, the patient had a deficiency for plasma cell differentiation of all major classes of immunoglobulins (IgG, IgA and IgM). Cross culture systems between normal T or B cells and the patient's T or B cells showed a defect of both T and B cell function.
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