Relationship between exophthalmogenic and thyroid-stimulating immunoglobulins in Graves' endocrine ophthalmopathy.

A Leövey, K Kálmán, T Szabó, K Lente, P Sándor, C Balázs
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Abstract

The effects of globulins from patients with Graves' infiltrative retrobulbar ophthalmopathy on the TSH binding inhibitory (TBIA) and stimulatory (TBSA) activities was examined utilising human thyroid Harderian gland (guinea-pig) plasma membranes in the TSh receptor assay. The changes of inhibitory and stimulatory activities of these globulins were observed following the preliminary incubation with human thyroid and Harderian gland plasma membranes. According to our data the TSh binding inhibitory activity of the globulins cases after saturating the samples with both thyroid and Harderian cell membranes. Whereas, their TSH-binding stimulatory activity ceases only after incubation with Harderian membrane. The TBSA of the samples after incubation with thyroid membrane increases significantly as compared to the values before incubation. We presume that the effects of the thyroid stimulating IgG (TSI) and the exophthalmogenic IgG (O-IgG) on the retrobulbar tissue are contradictory. It seems so the O-IgG is in some circumstances inhibited by TSI. Their TSH-binding inhibitory and stimulatory activities may depend on their quantitative ratio.

内分泌性眼病中促甲状腺免疫球蛋白与眼球突出性的关系。
利用人甲状腺哈德氏腺(豚鼠)质膜进行TSH受体测定,研究了Graves浸润性球后眼病患者球蛋白对TSH结合抑制(TBIA)和刺激(TBSA)活性的影响。在人甲状腺和哈德氏腺质膜上初步孵育后,观察了这些球蛋白的抑制和刺激活性的变化。根据我们的数据,在甲状腺和哈德氏细胞膜饱和样品后,球蛋白的TSh结合抑制活性下降。然而,它们的tsh结合刺激活性仅在与哈德氏膜孵育后停止。甲状腺膜孵育后样品的TBSA较孵育前显著增加。我们认为促甲状腺IgG (TSI)和致突出眼IgG (O-IgG)对球后组织的作用是相互矛盾的。在某些情况下,O-IgG似乎受到TSI的抑制。它们的tsh结合抑制和刺激活性可能取决于它们的数量比例。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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