[Factors altering purine metabolism in liver cells].

Abstract

This paper reviews results of a study of various factors altering 5-phosphoribosyl-1-pyrophosphate (PRPP) availability in freshly isolated rat liver cells. Total PRPP availability is not changed in the presence of allopurinol but in the competition for available PRPP is increased. Changes of PRPP availability due to phosphate, electron acceptors, or glycerol are usually accompanied by similar changes in the rate of purines synthesis de novo.