Biochemistry of antral ulcer in patients.

G Mózsik, J Kutas, L Nagy, F Tárnok
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Abstract

Separation and measurement of adenosine triphosphate (ATP), adenosine diphosphate (ADP), adenosine monophosphate (AMP), adenine-adenosine, lipid phosphates (lipid-P), RNA and DNA, furthermore, separation of Mg2+-dependent, total (Mg2+-dependent plus Na+--K+-dependent or Mg2+--Na+--K+-dependent) and Na+--K+-dependent ATPases and measured of their activities were carried out in tissue samples obtained from "ulcerated antral mucosa", from "non-ulcerated antral mucosa" and the muscular layer beneath the examined mucosa specimens, of patients with antral ulcer. It has been found that (1) the tissue levels of ATP, ADP and AMP, of the sum ATP + ADP + AMP, adenine-adenosine, lipid-P, RNA all calculated for 1.0 mg DNA content, further, the activities of Mg2+-dependent, total (Mg2+-dependent plus Na+--K+-dependent) and Na+--K+-dependent ATPase were significantly higher in the ulcerated antral mucosa than those in the control antral mucosa; (2) no significant biochemical alterations were found in the muscles under the ulcerated and non-ulcerated antral mucosa of patients with antral ulcer; (3) the extents of increases in the substrate levels of ulcerated antral mucosa depended on their original levels in the control antral mucosa. The results indicate a cellular hyperfunction in the ulcerated antral mucosa, in comparison with the control one. No circulatory injury could be demonstrated in the ulcerated antral mucosa.

胃窦溃疡患者的生化特征。
三磷酸腺苷(ATP)、二磷酸腺苷(ADP)、单磷酸腺苷(AMP)、腺嘌呤-腺苷、脂质磷酸(脂质- p)、RNA和DNA的分离和测定,以及Mg2+依赖性、总(Mg2+依赖性加Na+—K+依赖性或Mg2+—Na+—K+依赖性)和Na+—K+依赖性ATP酶的分离和活性测定。从胃窦溃疡患者的“未溃疡的胃窦黏膜”和检查粘膜标本下的肌肉层。结果表明:(1)在DNA含量为1.0 mg时,溃疡胃窦黏膜组织中ATP、ADP和AMP的水平,ATP + ADP + AMP、腺嘌呤-腺苷、脂质- p、RNA的总和均计算得到,Mg2+依赖性、总(Mg2+依赖性加Na+—K+依赖性)和Na+—K+依赖性ATP酶的活性显著高于对照胃窦黏膜;(2)胃窦溃疡患者溃疡和非溃疡胃窦黏膜下肌肉未见明显的生化改变;(3)溃疡胃窦黏膜底物水平的升高程度取决于其在对照组胃窦黏膜的原始水平。结果表明,与对照组相比,溃烂的胃窦粘膜细胞功能亢进。胃窦粘膜溃疡未见循环系统损伤。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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