A five-year immunological follow-up study of the institutionalized handicapped children vaccinated with live varicella vaccine or infected with natural varicella.

Biken journal Pub Date : 1984-09-01
K Ueda, K Tokugawa, F Nakashima, M Takahashi
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Abstract

Twenty-two institutionalized handicapped children who were susceptible to varicella were vaccinated with live varicella vaccine of the Oka strain and their immune status was followed for 5 years under conditions without exposure to natural varicella. Simultaneously, 7 children infected with natural varicella were followed. Of the 22 vaccinees, 16 showed sero-positive conversion by the fluorescent antibody to membrane antigen (FAMA) test, the other 6 remaining seronegative during 5 years of observation period. All the 16 cases showing seroconversion had detectable antibody for 5 years after vaccination, and 14 of them gave a positive reaction in the varicella skin test. All the 7 cases after natural varicella gave positive reactions in both the FAMA and skin test. These results suggest that immunity conferred by the vaccination would persist long even in the absence of exposure to natural varicella, though further follow-up studies are needed.

机构残疾儿童接种水痘活疫苗或感染天然水痘的五年免疫学随访研究。
对22例易患水痘的机构残疾儿童接种了Oka株水痘活疫苗,并在不接触天然水痘的条件下对其免疫状况进行了5年的随访。同时对7例自然水痘患儿进行随访。22例接种者经膜抗原荧光抗体(FAMA)试验血清转化为阳性16例,其余6例在5年观察期内血清转化为阴性。16例血清转化病例接种后5年内抗体均可检出,其中14例水痘皮试阳性。自然水痘后的7例患者FAMA和皮试均呈阳性反应。这些结果表明,即使在没有接触天然水痘的情况下,疫苗所赋予的免疫力也会持续很长时间,尽管还需要进一步的后续研究。
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