Studies of ovarian biopsies from women cyclically treated with the combination ethynodiol diacetate+mestranol alone and together with human menopausal gonadotrophin (Pergonal)+HCG.

P Pujol-Amat, J M Urgell-Roca, J Esteban-Altirriba, M Márquez-Ramirez
{"title":"Studies of ovarian biopsies from women cyclically treated with the combination ethynodiol diacetate+mestranol alone and together with human menopausal gonadotrophin (Pergonal)+HCG.","authors":"P Pujol-Amat, J M Urgell-Roca, J Esteban-Altirriba, M Márquez-Ramirez","doi":"10.1159/000302207","DOIUrl":null,"url":null,"abstract":"To assess Ovulens (1 mg. ethynodiol diacetate and .1 mg. mestranol) effectiveness a group of 39 women (aged 23 to 44) were treated with the drug for periods ranging from 1 to 24 cycles. In the last treatment cycle all women were operated upon and their ovarian function was assessed by direct inspection of the ovaries and by histological examination of ovarian biopsies. In 15 of the 39 women gonadotrophin HP-FSH or HMG (Pergonal) and HCG were administered to induce ovulation. Upon examination no fresh corpus luteum was found in the ovaries of the women treated with the oral contraceptive alone. In the group treated with the contraceptive and gonadotrophins 7 of 15 had functioning corpora lutea. These results demonstrate that Ovulen works as a contraceptive by inhibiting ovulation due to the suppression of pituitary gonadotrophins however a direct effect on the ovary can not be excluded.","PeriodicalId":73189,"journal":{"name":"Gynaecologia. International monthly review of obstetrics and gynecology. Revue internationale mensuelle d'obstetrique et de gynecologie. Monatsschrift fur Geburtshilfe und Gynakologie","volume":"167 4","pages":"237-49"},"PeriodicalIF":0.0000,"publicationDate":"1969-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000302207","citationCount":"9","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Gynaecologia. International monthly review of obstetrics and gynecology. Revue internationale mensuelle d'obstetrique et de gynecologie. Monatsschrift fur Geburtshilfe und Gynakologie","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1159/000302207","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 9

Abstract

To assess Ovulens (1 mg. ethynodiol diacetate and .1 mg. mestranol) effectiveness a group of 39 women (aged 23 to 44) were treated with the drug for periods ranging from 1 to 24 cycles. In the last treatment cycle all women were operated upon and their ovarian function was assessed by direct inspection of the ovaries and by histological examination of ovarian biopsies. In 15 of the 39 women gonadotrophin HP-FSH or HMG (Pergonal) and HCG were administered to induce ovulation. Upon examination no fresh corpus luteum was found in the ovaries of the women treated with the oral contraceptive alone. In the group treated with the contraceptive and gonadotrophins 7 of 15 had functioning corpora lutea. These results demonstrate that Ovulen works as a contraceptive by inhibiting ovulation due to the suppression of pituitary gonadotrophins however a direct effect on the ovary can not be excluded.
双乙酸乙二醇+美雌醇联合绝经期促性腺激素+HCG联合周期治疗女性卵巢活检的研究
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信