Urinary excretion of mucopolysaccharides in normal individuals and in the marfan syndrome

Gerald S. Berenson, Edward R. Dalferes Jr.
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引用次数: 48

Abstract

A study of the urinary excretion of mucopolysaccharides indicates a normal excretion of approx. 5–10 mg/24 h of a mixture of compounds. Although the major compounds normally excreted are the chondroitin sulfates (A, B, C), evidence is presented for the excretion of chondroitin, heparitin sulfate, and keratosulfate. The excretion appears to be somewhat greater in males and is increased around puberty. In the Marfan syndrome there is a two- to four-fold greater excretion but this is qualitatively similar to that for normal individuals. The mucopolysaccharide excreted in urine represents a small fraction relative to the amount metabolized in the body's connective tissue.

正常人和马凡氏综合征患者尿中粘多糖的排泄
一项对尿中粘多糖排泄的研究表明,正常的排泄量约为。5-10毫克/24小时的混合物的化合物。虽然通常排泄的主要化合物是硫酸软骨素(A、B、C),但有证据表明,硫酸软骨素、硫酸肝素和硫酸角化物也有排泄。男性的分泌量似乎更大,并且在青春期左右增加。马凡氏症患者的排尿量是正常人的两到四倍,但在质量上与正常人相似。尿中排泄的粘多糖相对于机体结缔组织代谢的量只占一小部分。
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