{"title":"Localization of oestradiol in the rat nasal mucosa.","authors":"E B Brittebo","doi":"10.1111/j.1600-0773.1985.tb00044.x","DOIUrl":null,"url":null,"abstract":"<p><p>The metabolism of 4-14C-oestradiol in the rodent respiratory tract has been investigated in vitro. Using thin-layer radiochromatography, at least 3 and 2 metabolites were found at incubation with slices from the rat olfactory mucosa and lung, respectively. Autoradiography of the nasal region of rats injected intravenously with 4-14C-oestradiol showed a high level of radioactivity in the mucosa covering the respiratory region, and in the subepithelial parts of the olfactory mucosa. Autoradiography of rat and mouse lung slices incubated with 4-14C-oestradiol showed that a selective localization of radioactivity occurred in the bronchial mucosa. The radioactivity in the mucosa of the respiratory tract was reversibly bound and could be extracted with organic solvents.</p>","PeriodicalId":6972,"journal":{"name":"Acta pharmacologica et toxicologica","volume":"57 4","pages":"285-90"},"PeriodicalIF":0.0000,"publicationDate":"1985-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1600-0773.1985.tb00044.x","citationCount":"19","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta pharmacologica et toxicologica","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1111/j.1600-0773.1985.tb00044.x","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 19
Abstract
The metabolism of 4-14C-oestradiol in the rodent respiratory tract has been investigated in vitro. Using thin-layer radiochromatography, at least 3 and 2 metabolites were found at incubation with slices from the rat olfactory mucosa and lung, respectively. Autoradiography of the nasal region of rats injected intravenously with 4-14C-oestradiol showed a high level of radioactivity in the mucosa covering the respiratory region, and in the subepithelial parts of the olfactory mucosa. Autoradiography of rat and mouse lung slices incubated with 4-14C-oestradiol showed that a selective localization of radioactivity occurred in the bronchial mucosa. The radioactivity in the mucosa of the respiratory tract was reversibly bound and could be extracted with organic solvents.
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