A captive solvent method for rapid radiosynthesis: Application to the synthesis of [1-11C]palmitic acid

Abstract

A method is described for the synthesis of [1-¹¹C]palmitic acid,in which ¹¹CO₂ is reacted with a Grignard reagent trapped within the pores of microporous polypropylene powder in a column. The free acid is liberated by passing gaseous HCl through the column. The apparatus is very simple, facilitating automation and miniaturization of the synthesis.