1-Alpha-OH-cholecalciferol (1-alpha-OH-D3) and optimal calcium intake in calcium deficiency osteoporosis mediated by parathyroid activity morphologic and biochemical changes in adult male rats.
{"title":"1-Alpha-OH-cholecalciferol (1-alpha-OH-D3) and optimal calcium intake in calcium deficiency osteoporosis mediated by parathyroid activity morphologic and biochemical changes in adult male rats.","authors":"T S Lindholm, O S Nilsson, T C Lindholm","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>By feeding adult male rats a calcium deficient diet for a period of 6 weeks osteoporosis can be induced with respect to significant changes in mass, turnover, chemical composition, and morphology of bone and parathyroid glands. When subsequently treating the osteoporotic rats with a combination of 1-alpha-OH-cholecalciferol (1-alpha-OH-D3) and optimal calcium intake osteoporosis as well as morphologic changes of parathyroids can be almost totally reversed as soon as after 2 weeks and completely after 4 and 6 weeks. Notwithstanding the change to an optimal calcium intake seems to be more important in normalizing the osteoporotic skeleton resulting from calcium deficiency than is the ingestion of 1-alpha-OH-D3, which may per se induce new bone formation.</p>","PeriodicalId":75427,"journal":{"name":"Acta vitaminologica et enzymologica","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta vitaminologica et enzymologica","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
By feeding adult male rats a calcium deficient diet for a period of 6 weeks osteoporosis can be induced with respect to significant changes in mass, turnover, chemical composition, and morphology of bone and parathyroid glands. When subsequently treating the osteoporotic rats with a combination of 1-alpha-OH-cholecalciferol (1-alpha-OH-D3) and optimal calcium intake osteoporosis as well as morphologic changes of parathyroids can be almost totally reversed as soon as after 2 weeks and completely after 4 and 6 weeks. Notwithstanding the change to an optimal calcium intake seems to be more important in normalizing the osteoporotic skeleton resulting from calcium deficiency than is the ingestion of 1-alpha-OH-D3, which may per se induce new bone formation.
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