F Nolasco, J S Cameron, J Hicks, C S Ogg, D G Williams
{"title":"Adult-onset nephrotic syndrome with minimal changes: response to corticosteroids and cyclophosphamide.","authors":"F Nolasco, J S Cameron, J Hicks, C S Ogg, D G Williams","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Eighty-nine patients with onset of nephrotic syndrome over the age of 15 years and minimal changes on renal biopsy have been studied. Seventy-five patients were given a course of prednisone in an initial dosage of 60mg/24hr, tapering over the following 8-16 weeks. Only 45 were in remission after eight week's treatment, 55 after 16 weeks; eventually, a total of 58 lost their proteinuria completely. Of these, 24 per cent never relapsed, 56 per cent relapsed on a single occasion or infrequently, and only 21 per cent were frequent relapsers. Cyclophosphamide, used in 36 patients, had a similar time to response. Stability of remission was better than in similar children, 66 per cent being in remission at five years, after which no further relapses were seen.</p>","PeriodicalId":77886,"journal":{"name":"Proceedings of the European Dialysis and Transplant Association - European Renal Association. European Dialysis and Transplant Association - European Renal Association. Congress","volume":"21 ","pages":"588-93"},"PeriodicalIF":0.0000,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Proceedings of the European Dialysis and Transplant Association - European Renal Association. European Dialysis and Transplant Association - European Renal Association. Congress","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Eighty-nine patients with onset of nephrotic syndrome over the age of 15 years and minimal changes on renal biopsy have been studied. Seventy-five patients were given a course of prednisone in an initial dosage of 60mg/24hr, tapering over the following 8-16 weeks. Only 45 were in remission after eight week's treatment, 55 after 16 weeks; eventually, a total of 58 lost their proteinuria completely. Of these, 24 per cent never relapsed, 56 per cent relapsed on a single occasion or infrequently, and only 21 per cent were frequent relapsers. Cyclophosphamide, used in 36 patients, had a similar time to response. Stability of remission was better than in similar children, 66 per cent being in remission at five years, after which no further relapses were seen.
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