An integration of physiological, morphological and biochemical assessments in studying guinea pig models of ototoxicity and otoprotection−a systematic review

IF 2.9 Q2 TOXICOLOGY

Current Research in Toxicology Pub Date : 2026-01-01 Epub Date: 2026-03-16 DOI:10.1016/j.crtox.2026.100292

Yi-Ho Young , Po-Hsuan Wu , Shing-Hwa Liu

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Abstract

Purpose

This systematic review aims to explore the development and utilization of a comprehensive test battery comprising physiological, morphological, and biochemical assessments in guinea pig models to study mechanisms of ototoxicity and otoprotection.

Methods

This review was developed from peer-reviewed articles almost exclusively dealing with guinea pigs published in those journals listed on Journal Citation Reports.

Results

Initially, 560 articles were retrieved from 1994 to 2024. Following the guidelines (PRISMA 2020 statement) for reporting reviews, 54 relevant papers were ultimately selected.

Conclusion

Using animal models of ototoxicity and otoprotection, particularly the guinea pig can provide valuable insights into the mechanisms underlying ototoxicity and otoprotection in humans. This approach offers a detailed framework for elucidating ototoxic mechanisms and exploring therapeutic strategies for otoprotection, while also encouraging researchers to pursue basic research in this field.

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豚鼠耳毒性和耳保护模型的生理、形态学和生化综合评价综述

目的通过对豚鼠耳毒性和耳保护机制的研究，探讨一种包括生理、形态和生化评价的综合测试电池的开发与应用。方法本综述从同行评议的文章中发展而来，这些文章几乎都是关于豚鼠的，发表在期刊引文报告中列出的期刊上。结果初步检索了1994 - 2024年间的560篇文献。根据报告评审指南（PRISMA 2020声明），最终选择了54篇相关论文。结论建立耳毒性和耳保护动物模型，特别是豚鼠耳毒性和耳保护动物模型，对人类耳毒性和耳保护机制的研究具有重要意义。该方法为阐明耳毒性机制和探索耳保护的治疗策略提供了详细的框架，同时也鼓励了研究人员在这一领域进行基础研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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