The NLRP3 inhibitor, MCC950, attenuates environmental pollutant PM2.5-induced acute lung injury by inhibiting alveolar macrophage pyroptosis

IF 2.9 Q2 TOXICOLOGY

Current Research in Toxicology Pub Date : 2026-01-01 Epub Date: 2026-01-22 DOI:10.1016/j.crtox.2026.100282

Zhuoxiao Han , Ying Han , Ranran Li , Kexin Fan , Xiao Zhang , Tengfei Sun , Yue Li , Hua Qiao

引用次数: 0

Abstract

PM_2.5 is a key environmental pollutant that induces inflammatory lung injury.

Effective prevention and treatment for PM₂.₅-induced lung damage remain lacking.

This study investigated MCC950′s protective role in PM₂.₅-exposed mice and macrophages.

PM₂.₅ triggers NLRP3/Caspase-1-mediated pyroptosis, amplifying pulmonary inflammation.

MCC950 attenuates injury by inhibiting pyroptosis, suggesting therapeutic potential.

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NLRP3抑制剂MCC950通过抑制肺泡巨噬细胞焦亡来减轻环境污染物pm2.5引起的急性肺损伤。

PM2.5是诱发炎性肺损伤的关键环境污染物。对pm2.5引起的肺损伤仍然缺乏有效的预防和治疗。本研究探讨了MCC950对pm2.5暴露小鼠和巨噬细胞的保护作用。PM2.5触发NLRP3/ caspase -1介导的焦亡，放大肺部炎症。MCC950通过抑制焦亡减轻损伤，提示治疗潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Research in Toxicology Environmental Science-Health, Toxicology and Mutagenesis

CiteScore

4.70

自引率

3.00%

发文量

审稿时长

82 days