Immunocytochemical study of glutathione peroxidase in normal rat kidney.

Renal physiology Pub Date : 1986-01-01 DOI:10.1159/000173089
S Mizuiri, K Hirata, S Izumi, N Komatsu, S Yoshimura, K Watanabe
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引用次数: 2

Abstract

In the normal rat kidney, immunohistochemical localization of glutathione peroxidase (GSH-Po) was mainly in the proximal tubules (PTs), where the proximal portions (S1 + S2) were more intensely stained than the distal portion (S3). Immunocytochemically, GSH-Po was localized in cytosol including the core of microvilli and lysosomes of the epithelial cells in the PTs. Since albumin and IgG were not found in cytosol, it is suggested that cytosolic GSH-Po may be generated in situ, but is not derived from the serum.

正常大鼠肾谷胱甘肽过氧化物酶的免疫细胞化学研究。
在正常大鼠肾脏中,谷胱甘肽过氧化物酶(GSH-Po)的免疫组织化学定位主要在近端小管(PTs),其中近端部分(S1 + S2)比远端部分(S3)染色更强烈。免疫细胞化学表明,GSH-Po定位于包括上皮细胞微绒毛核心和溶酶体在内的细胞质中。由于细胞质中未发现白蛋白和IgG,提示细胞质中GSH-Po可能是原位生成的,而不是来源于血清。
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