Thyroid volume as a marker of early atherosclerosis in women with PCOS: association with carotid intima-media thickness.

IF 2.1 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Biomarkers in medicine Pub Date : 2026-02-16 DOI:10.1080/17520363.2026.2631622

Kadircan Karatoprak, Emre Sedar Saygılı, Hayri Bostan, Ersen Karakılıç

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引用次数: 0

Abstract

Aim: This study aimed to evaluate the determinants of thyroid volume (TV) in euthyroid women with polycystic ovary syndrome (PCOS) and to assess the association between TV and cardiovascular risk, with a particular focus on carotid intima - media thickness (CIMT).

Methods: This cross-sectional study included 100 participants (46 women with PCOS and 54 age-matched healthy controls). Only euthyroid participants were enrolled. TV was measured by ultrasonography, and CIMT was evaluated as a marker of early atherosclerosis. Biochemical markers were recorded. Multiple regression and receiver operating characteristic (ROC) analyses were performed.

Results: Women with PCOS had significantly higher TV compared to controls [13.4 ml (IQR: 9.8-17.4) vs. 11.3 ml (IQR: 9.6-12.9), p = 0.041]. TV was positively correlated with BMI (r = 0.485, p < 0.001), waist circumference (r = 0.419, p = 0.004), and HOMA-IR (r = 0.406, p = 0.005). CIMT was independently predicted by total testosterone (β = 0.296, p = 0.040), LH/FSH ratio (β = -0.398, p = 0.005) and TV (β = 0.306, p = 0.036). ROC analysis showed that TV moderately predicted elevated CIMT (AUC = 0.68; optimal cutoff =14.5 mL).

Discussion: TV was independently associated with CIMT in euthyroid women with PCOS, suggesting that thyroid morphology may serve as a complementary, noninvasive marker of early atherosclerotic changes.

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甲状腺体积作为PCOS女性早期动脉粥样硬化的标志：与颈动脉内膜-中膜厚度的关系。

目的：本研究旨在评估甲状腺功能正常的多囊卵巢综合征（PCOS）女性甲状腺体积（TV）的决定因素，并评估TV与心血管风险之间的关系，特别关注颈动脉内膜-中膜厚度（CIMT）。方法：这项横断面研究包括100名参与者（46名多囊卵巢综合征女性和54名年龄匹配的健康对照）。只有甲状腺功能正常的参与者被纳入研究。通过超声测量TV，并评价CIMT作为早期动脉粥样硬化的标志。记录生化指标。进行多元回归分析和受试者工作特征（ROC）分析。结果：PCOS女性的TV明显高于对照组[13.4 ml (IQR: 9.8-17.4) vs. 11.3 ml (IQR: 9.6-12.9), p = 0.041]。TV与BMI （r = 0.485, p r = 0.419, p = 0.004）、HOMA-IR （r = 0.406, p = 0.005）呈正相关。总睾酮（β = 0.296, p = 0.040）、LH/FSH比值（β = -0.398, p = 0.005）和TV （β = 0.306, p = 0.036）独立预测CIMT。ROC分析显示，TV中度预测CIMT升高（AUC = 0.68；最佳截止值=14.5 mL）。讨论：TV独立与甲状腺功能正常的PCOS女性的CIMT相关，提示甲状腺形态可以作为早期动脉粥样硬化改变的一种补充的、无创的标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomarkers in medicine 医学-医学：研究与实验

CiteScore

3.80

自引率

4.50%

发文量

审稿时长

6-12 weeks

期刊介绍： Biomarkers are physical, functional or biochemical indicators of physiological or disease processes. These key indicators can provide vital information in determining disease prognosis, in predicting of response to therapies, adverse events and drug interactions, and in establishing baseline risk. The explosion of interest in biomarker research is driving the development of new predictive, diagnostic and prognostic products in modern medical practice, and biomarkers are also playing an increasingly important role in the discovery and development of new drugs. For the full utility of biomarkers to be realized, we require greater understanding of disease mechanisms, and the interplay between disease mechanisms, therapeutic interventions and the proposed biomarkers. However, in attempting to evaluate the pros and cons of biomarkers systematically, we are moving into new, challenging territory. Biomarkers in Medicine (ISSN 1752-0363) is a peer-reviewed, rapid publication journal delivering commentary and analysis on the advances in our understanding of biomarkers and their potential and actual applications in medicine. The journal facilitates translation of our research knowledge into the clinic to increase the effectiveness of medical practice. As the scientific rationale and regulatory acceptance for biomarkers in medicine and in drug development become more fully established, Biomarkers in Medicine provides the platform for all players in this increasingly vital area to communicate and debate all issues relating to the potential utility and applications. Each issue includes a diversity of content to provide rounded coverage for the research professional. Articles include Guest Editorials, Interviews, Reviews, Research Articles, Perspectives, Priority Paper Evaluations, Special Reports, Case Reports, Conference Reports and Company Profiles. Review coverage is divided into themed sections according to area of therapeutic utility with some issues including themed sections on an area of topical interest. Biomarkers in Medicine provides a platform for commentary and debate for all professionals with an interest in the identification of biomarkers, elucidation of their role and formalization and approval of their application in modern medicine. The audience for Biomarkers in Medicine includes academic and industrial researchers, clinicians, pathologists, clinical chemists and regulatory professionals.