Insoluble uricase in liver peroxisomes of old world monkeys

Abstract

• 1.

  1. Subcellular localization form and properties of liver uricase of Macaca fascicularis were examined.

• 2.

  2. Uricase was present as the insoluble form in the peroxisomal core.

• 3.

  3. Evidence was obtained to show that the peroxisomal core in uricase itself.

• 4.

  4. The number and mol. wts of the subunits of the enzyme were identical to those of rat liver uricase.

• 5.

  5. The same results were also obtained for liver uricase of Macaca fuscata.