Efficient and specific DNA-targeting using single-stranded LNA/MOE mixmers and chimeric Invader:XenoRNA probes.

IF 2.7 3区化学 Q1 CHEMISTRY, ORGANIC

Organic & Biomolecular Chemistry Pub Date : 2025-10-20 DOI:10.1039/d5ob01570g

Michaela E Everly, Patrick J Hrdlicka

引用次数: 0

Abstract

DNA-targeting properties of heteroduplexes between intercalator-functionalized oligonucleotides and various Xeno RNAs (i.e., LNA/MOE mixmers, or fully modified MOE, O2'-Me, or 2'-F strands) are disclosed. Chimeric Invader:LNA/MOE probes and some single-stranded LNA/MOE mixmers enable efficient invasion of double-stranded DNA targets with exceptional binding specificity.

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利用单链LNA/MOE混频器和嵌合Invader:XenoRNA探针高效特异的dna靶向。

揭示了插入器功能化寡核苷酸和各种Xeno rna（即LNA/MOE混合物，或完全修饰的MOE， O2'-Me或2'-F链）之间的异双链的dna靶向特性。嵌合入侵者：LNA/MOE探针和一些单链LNA/MOE混合器能够有效入侵双链DNA靶标，具有特殊的结合特异性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic & Biomolecular Chemistry 化学-有机化学

CiteScore

5.50

自引率

9.40%

发文量

1056

审稿时长

1.3 months

期刊介绍： Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.