Lanostane–Meroterpene Conjugates with Unusual Aryl Ether Linkage and a Lanostane Dimer from Artificially Cultivated Fruiting Bodies of Ganoderma cf. hochiminhense

Abstract

Ten previously undescribed compounds, including eight lanostane–meroterpene conjugates, ganohochimins A–H (1–8), a lanostane dimer, ganohochimate A (9), and a meroterpenoid, fornicin F (10), were isolated from the cultivated mushroom Ganoderma cf. hochiminhense(strain TBRC-BCC 22084). The 24S-configuration of ganohochimin A (1) was determined by cleavage of the aryl ether under acidic conditions. The structure of ganohochimate A (9) was confirmed by alkaline hydrolysis to cleave into two lanostane units. Ganohochimins exhibited cytotoxicity against NCI-H187 (small-cell lung cancer) cells (IC₅₀ 7.7–33 μM) and noncancerous Vero cells (IC₅₀ 6.3–30 μM).