An unusual association between HIV and Creutzfeldt-Jakob disease in a patient from northeastern Brazil

IF 2.8 4区医学 Q2 INFECTIOUS DISEASES

Brazilian Journal of Infectious Diseases Pub Date : 2025-10-11 DOI:10.1016/j.bjid.2025.104590

José Wagner Leonel Tavares-Júnior , Francisco José Basílio , Francisco Edson Buhamra Abreu , Lucas Rodrigues Tomaz dos Santos , Pablo Picasso de Araújo Coimbra , Érico Antonio Gomes de Arruda

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引用次数: 0

Abstract

Prion diseases are significant contributors to rapidly progressive dementia. Among these conditions, sporadic Creutzfeldt-Jakob Disease (CJD) is the most prevalent, characterized by its rarity, lack of treatment options, and rapid progression to fatality. Diagnosis relies on a combination of clinical symptoms and specific alterations detected in brain MRI, EEG, and CSF analysis. The present study details the case of a 53-year-old individual from Fortaleza, Brazil, diagnosed with sporadic CJD, confirmed through clinical presentation and a series of diagnostic evaluations, including 14-3-3 protein detection and RT-QuIC analysis. Differential diagnoses were considered to rule out other rapidly progressing conditions, such as infectious and immune-related diseases, ultimately leading to a likely diagnosis of sporadic CJD.

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一名巴西东北部患者的HIV与克雅氏病之间的不寻常联系

朊病毒疾病是导致快速进展性痴呆的重要因素。在这些疾病中，散发的克雅氏病（CJD）最为普遍，其特点是罕见、缺乏治疗选择和迅速发展至死亡。诊断依赖于临床症状和在脑MRI、脑电图和脑脊液分析中检测到的特定改变的结合。本研究详细介绍了一名来自巴西Fortaleza的53岁患者，通过临床表现和一系列诊断评估（包括14-3-3蛋白检测和RT-QuIC分析）确诊为散发性克雅氏病。鉴别诊断被认为排除了其他快速发展的疾病，如传染性和免疫相关疾病，最终导致可能的散发CJD诊断。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Brazilian Journal of Infectious Diseases 医学-传染病学

CiteScore

5.50

自引率

0.00%

发文量

925

审稿时长

41 days

期刊介绍： The Brazilian Journal of Infectious Diseases is the official publication of the Brazilian Society of Infectious Diseases (SBI). It aims to publish relevant articles in the broadest sense on all aspects of microbiology, infectious diseases and immune response to infectious agents. The BJID is a bimonthly publication and one of the most influential journals in its field in Brazil and Latin America with a high impact factor, since its inception it has garnered a growing share of the publishing market.