{"title":"Epigenetic control of the plant metabolome: implications for Chinese medicine.","authors":"Tae Kyung Hyun","doi":"10.1186/s13020-025-01217-8","DOIUrl":null,"url":null,"abstract":"<p><p>Epigenetic regulation-including DNA methylation, histone modifications, and small RNAs-plays a crucial role in modulating specialized metabolism in plants; specialized metabolites confer crucial pharmacological properties to plants, forming the basis of traditional Chinese medicine (TCM). Recent studies have highlighted the influence of these mechanisms on metabolite production in key medicinal plants such as Papaver somniferum and Salvia miltiorrhiza. Emerging technologies such as CRISPR/dCas9-based epigenome editing and miRNA modulation enable precise control of biosynthetic pathways. Integrating these molecular-level strategies into TCM research and the cultivation of medicinal plants could improve the efficacy and consistency of herbal medicinal products, providing molecular tools for the targeted regulation of active ingredients and thereby facilitating the modernization of TCM.</p>","PeriodicalId":10266,"journal":{"name":"Chinese Medicine","volume":"20 1","pages":"165"},"PeriodicalIF":5.7000,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12498456/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chinese Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s13020-025-01217-8","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"INTEGRATIVE & COMPLEMENTARY MEDICINE","Score":null,"Total":0}
引用次数: 0
Abstract
Epigenetic regulation-including DNA methylation, histone modifications, and small RNAs-plays a crucial role in modulating specialized metabolism in plants; specialized metabolites confer crucial pharmacological properties to plants, forming the basis of traditional Chinese medicine (TCM). Recent studies have highlighted the influence of these mechanisms on metabolite production in key medicinal plants such as Papaver somniferum and Salvia miltiorrhiza. Emerging technologies such as CRISPR/dCas9-based epigenome editing and miRNA modulation enable precise control of biosynthetic pathways. Integrating these molecular-level strategies into TCM research and the cultivation of medicinal plants could improve the efficacy and consistency of herbal medicinal products, providing molecular tools for the targeted regulation of active ingredients and thereby facilitating the modernization of TCM.
Chinese MedicineINTEGRATIVE & COMPLEMENTARY MEDICINE-PHARMACOLOGY & PHARMACY
CiteScore
7.90
自引率
4.10%
发文量
133
审稿时长
31 weeks
期刊介绍：
Chinese Medicine is an open access, online journal publishing evidence-based, scientifically justified, and ethical research into all aspects of Chinese medicine.
Areas of interest include recent advances in herbal medicine, clinical nutrition, clinical diagnosis, acupuncture, pharmaceutics, biomedical sciences, epidemiology, education, informatics, sociology, and psychology that are relevant and significant to Chinese medicine. Examples of research approaches include biomedical experimentation, high-throughput technology, clinical trials, systematic reviews, meta-analysis, sampled surveys, simulation, data curation, statistics, omics, translational medicine, and integrative methodologies.
Chinese Medicine is a credible channel to communicate unbiased scientific data, information, and knowledge in Chinese medicine among researchers, clinicians, academics, and students in Chinese medicine and other scientific disciplines of medicine.
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