Yuan-Hai Sun, Ya-Qian Feng, Sun-Ying Cheng, Ling-Huan Li, Han-Bing Li
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引用次数: 0
Abstract
Adipose tissue thermogenesis, both uncoupling protein 1 (UCP1)-dependent and independent thermogenesis, plays a critical role in the homeostasis of whole-body metabolism. Emerging evidence demonstrates that key nodes in adipose tissue thermogenesis can be regulated by dynamic and reversible N6-methyladenosine (m6A) modification, which is one of the most prevalent and extensively studied RNA modifications. Furthermore, its dysregulation drives the pathogenesis of obesity and related metabolic disorders. In this review, we elucidate the role and molecular mechanisms of m6A modification in adipose tissue thermogenesis, highlight potential therapeutic strategies for promoting thermogenic remodeling of adipose tissue through targeting m6A modification, and discuss future research directions in this field. The insights provide clues for translational research aimed at developing m6A-based therapies for metabolic diseases.
期刊介绍：
Obesity Reviews is a monthly journal publishing reviews on all disciplines related to obesity and its comorbidities. This includes basic and behavioral sciences, clinical treatment and outcomes, epidemiology, prevention and public health. The journal should, therefore, appeal to all professionals with an interest in obesity and its comorbidities.
Review types may include systematic narrative reviews, quantitative meta-analyses and narrative reviews but all must offer new insights, critical or novel perspectives that will enhance the state of knowledge in the field.
The editorial policy is to publish high quality peer-reviewed manuscripts that provide needed new insight into all aspects of obesity and its related comorbidities while minimizing the period between submission and publication.
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