Adult-Onset Partial Unilateral Lentiginosis: A Rare Pigmentary Mosaicism With Clinical Response to Tranexamic Acid

IF 0.6 Q3 MEDICINE, GENERAL & INTERNAL
Niranjan Pudasaini, Sabin Poudel, Aashutosh Pokharel, Anup Mishra, Anil Kumar Singh Dangol, Manisha Chapagain
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Abstract

Partial unilateral lentiginosis (PUL) is a rare pigmentary disorder characterized by numerous lentigines grouped within normal skin in a segmental pattern with sharp demarcation at the midline. The authors hereby present a case of a 40-year-old female, who presented with multiple asymptomatic, gradually progressive, brownish flat skin lesions on her left breast, abdomen, and left half of the trunk for 16 years. Diagnosis was made clinically via properly documented history, physical examination, and histopathological evaluation. Although treatment is unnecessary, many patients seek consultations for cosmetic reasons. Our patient is showing a good response to the prescribed tablet tranexamic acid and topical kojic acid cream, along with regular application of sun protection cream SPF 50+. This is a rare case of adult-onset PUL showing good clinical improvement with oral tranexamic acid combined with kojic acid cream.

Abstract Image

成人发病的部分单侧黄斑病:一种罕见的色素镶嵌病,对氨甲环酸有临床反应
部分单侧小痣病(PUL)是一种罕见的色素性疾病,其特征是在正常皮肤中有许多小痣以节段形式聚集在一起,在中线有明显的界限。作者在此报告一个40岁的女性病例,她在左乳房,腹部和左半躯干出现多重无症状,逐渐进展的棕色扁平皮肤病变,持续16年。临床诊断是通过适当的记录病史,体格检查和组织病理学评估。虽然治疗是不必要的,许多患者寻求咨询美容的原因。我们的病人对处方的氨甲环酸片剂和外用曲酸乳膏有很好的反应,并定期使用SPF 50+的防晒霜。这是一个罕见的成人发病PUL病例,口服氨甲环酸联合曲酸乳膏后临床改善良好。
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来源期刊
Clinical Case Reports
Clinical Case Reports MEDICINE, GENERAL & INTERNAL-
自引率
14.30%
发文量
1268
审稿时长
13 weeks
期刊介绍: Clinical Case Reports is different from other case report journals. Our aim is to directly improve global health and increase clinical understanding using case reports to convey important best practice information. We welcome case reports from all areas of Medicine, Nursing, Dentistry, and Veterinary Science and may include: -Any clinical case or procedure which illustrates an important best practice teaching message -Any clinical case or procedure which illustrates the appropriate use of an important clinical guideline or systematic review. As well as: -The management of novel or very uncommon diseases -A common disease presenting in an uncommon way -An uncommon disease masquerading as something more common -Cases which expand understanding of disease pathogenesis -Cases where the teaching point is based on an error -Cases which allow us to re-think established medical lore -Unreported adverse effects of interventions (drug, procedural, or other).
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