Visible‐Light‐Promoted Cascade Acylmethylation/Annulation of N‐Alkene‐Linked Indoles with Sulfoxonium Ylides: Synthesis of Acylmethylated Pyrrolo[1,2‐a]indoles

IF 2.7 3区化学 Q2 CHEMISTRY, ORGANIC

European Journal of Organic Chemistry Pub Date : 2025-10-04 DOI:10.1002/ejoc.202500619

Fan Wu, Yuzhen Xie, Hongni Qin, Yong Zhang, Song Sun

引用次数: 0

Abstract

A visible‐light‐promoted sequential radical acylmethylation/annulation of unactivated alkenes with sulfoxonium ylides has been developed, furnishing a range of acylmethylated pyrrolo[1,2‐a]indoles in high efficiency under photoredox conditions. Notably, this reaction is characterized by mild conditions, operational simplicity, a wide substrate scope, and excellent functional group tolerance.

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可见光促进N -烯烃连接的吲哚与亚砜酰化的级联酰基甲基化/环化：酰基甲基化吡咯[1,2 - a]吲哚的合成

在光氧化还原条件下，研究人员开发了一种可见光促进的非活化烯烃与亚砜酰化的顺序自由基甲基化/环化方法，以高效率地制备了一系列酰基甲基化吡咯[1,2 - A]吲哚。值得注意的是，该反应具有条件温和、操作简单、底物范围广和良好的官能团耐受性等特点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Organic Chemistry 化学-有机化学

CiteScore

5.40

自引率

3.60%

发文量

752

审稿时长

1 months

期刊介绍： The European Journal of Organic Chemistry (2019 ISI Impact Factor 2.889) publishes Full Papers, Communications, and Minireviews from the entire spectrum of synthetic organic, bioorganic and physical-organic chemistry. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies. The following journals have been merged to form two leading journals, the European Journal of Organic Chemistry and the European Journal of Inorganic Chemistry: Liebigs Annalen Bulletin des Sociétés Chimiques Belges Bulletin de la Société Chimique de France Gazzetta Chimica Italiana Recueil des Travaux Chimiques des Pays-Bas Anales de Química Chimika Chronika Revista Portuguesa de Química ACH—Models in Chemistry Polish Journal of Chemistry.