Emily Houston , Sean Boyd , Vivikta Iyer , James Boyd , Deepak Gupta
{"title":"The need for developing consensus-based guidelines in assessing Parkinson's disease laterality","authors":"Emily Houston , Sean Boyd , Vivikta Iyer , James Boyd , Deepak Gupta","doi":"10.1016/j.parkreldis.2025.108067","DOIUrl":null,"url":null,"abstract":"<div><div>This study investigated the correlation between Parkinson's disease laterality, as defined by the <strong>Hoehn and Yahr (HY) scale</strong>, and <strong>appendicular parkinsonism scores</strong> from the <strong>MDS-UPDRS Part III</strong> using the <strong>PPMI dataset</strong>. While most cases (89.6 %) showed congruence, a 10.4 % discordance suggests that factors beyond appendicular parkinsonism influence clinical HY staging, highlighting a need for standardized guidelines.</div></div>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"140 ","pages":"Article 108067"},"PeriodicalIF":3.4000,"publicationDate":"2025-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Parkinsonism & related disorders","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1353802025008089","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
This study investigated the correlation between Parkinson's disease laterality, as defined by the Hoehn and Yahr (HY) scale, and appendicular parkinsonism scores from the MDS-UPDRS Part III using the PPMI dataset. While most cases (89.6 %) showed congruence, a 10.4 % discordance suggests that factors beyond appendicular parkinsonism influence clinical HY staging, highlighting a need for standardized guidelines.
期刊介绍:
Parkinsonism & Related Disorders publishes the results of basic and clinical research contributing to the understanding, diagnosis and treatment of all neurodegenerative syndromes in which Parkinsonism, Essential Tremor or related movement disorders may be a feature. Regular features will include: Review Articles, Point of View articles, Full-length Articles, Short Communications, Case Reports and Letter to the Editor.