Regioselective terminal bromination of fluorinated oligophenylenes.

Abstract

Herein, we demonstrate an unprecedentedly selective terminal bromination of fluorinated biphenylenes and oligophenylenes in the presence of excess metallic iron. The reaction can be carried out under ambient conditions at room temperature, yielding the target compounds with up to 98% yield. The high regioselectivity and scalability make this approach superior to existing methods.