β-Carboxyphospholes via carboxylative desilylation: luminophores with a versatile connectivity attached

Abstract

The synthesis of a β-carboxyphospholes has been achieved via carboxylative desilylation of its β-TMS substituted analogue in CO₂ atmosphere. The scaffold allows facile functionalization of the title carboxylic acid including the respective acyl chloride, carboxamide, ester, anhydride compatible with bioconjugation while the integrity of the phosphole unit is maintained.