Metabolic dysfunction-associated steatotic liver disease: an emerging comorbidity in COPD.

IF 2.8 3区 医学 Q2 PHARMACOLOGY & PHARMACY
Therapeutic Advances in Chronic Disease Pub Date : 2025-09-27 eCollection Date: 2025-01-01 DOI:10.1177/20406223251378868
Ali Al Dailaty, Ahmad Ghanem, Ghaydaa Abou Daher, Toufic Chaaban, Rajaa Chatila
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引用次数: 0

Abstract

Chronic obstructive pulmonary disease (COPD) and metabolic dysfunction-associated steatotic liver disease (MASLD) are highly prevalent conditions that frequently coexist. MASLD, now the leading cause of chronic liver disease globally, affects up to 25% of the population and is increasingly recognized in COPD patients. Shared cardiometabolic risk factors, chronic inflammation, and lipid-mediated injury underpin their pathophysiological link. This review outlines the epidemiology, shared mechanisms, and clinical impact of MASLD in COPD, as well as diagnostic strategies and current management approaches. Recognizing MASLD as a clinically significant comorbidity in COPD may offer new opportunities for risk stratification, integrated care, and targeted therapeutic interventions, underscoring the need for further research into their mechanistic interplay and bidirectional impact.

代谢功能障碍相关的脂肪变性肝病:慢性阻塞性肺病的新并发疾病
慢性阻塞性肺疾病(COPD)和代谢功能障碍相关的脂肪变性肝病(MASLD)是高度流行的疾病,经常共存。MASLD现在是全球慢性肝病的主要病因,影响多达25%的人口,并且在COPD患者中得到越来越多的认识。共同的心脏代谢危险因素、慢性炎症和脂质介导的损伤巩固了它们的病理生理联系。这篇综述概述了MASLD在COPD中的流行病学、共同机制和临床影响,以及诊断策略和当前的管理方法。认识到MASLD作为COPD的临床显著合并症可能为风险分层、综合护理和有针对性的治疗干预提供新的机会,强调需要进一步研究其机制相互作用和双向影响。
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来源期刊
Therapeutic Advances in Chronic Disease
Therapeutic Advances in Chronic Disease Medicine-Medicine (miscellaneous)
CiteScore
6.20
自引率
0.00%
发文量
108
审稿时长
12 weeks
期刊介绍: Therapeutic Advances in Chronic Disease publishes the highest quality peer-reviewed research, reviews and scholarly comment in the drug treatment of all chronic diseases. The journal has a strong clinical and pharmacological focus and is aimed at clinicians and researchers involved in the medical treatment of chronic disease, providing a forum in print and online for publishing the highest quality articles in this area.
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