Metabolomics of Trichoderma spirale by Mass Spectrometry Data Dereplication

Abstract

Trichoderma spirale is an endophytic fungus with diverse biological activities, including bioherbicidal effects through photosynthesis inhibition in weeds. This study investigated the metabolome of T. spirale using mass spectrometry data dereplication via a molecular networking approach. The metabolites identified include isolongifolol, curcumol, L-leucyl-L-proline lactam, azelaic acid, and 2-hydroxyisocaproic acid. Thus, this work represents a significant contribution to the study of the T. spirale metabolome, revealing for the first time the presence of 27 metabolites in this species, including eight previously known metabolites of the Trichoderma genus.