Nucleosome Linker Length and Distribution as Major Players in Epigenetic Regulation: Insights from Cryo-Electron Microscopy and Modeling of Retina Cell Maturation.

Abstract

We summarize recent findings on the conformational differences of chromatin fibers in immature versus mature retina cells due to different nucleosome linker length values and distributions, as revealed by cryo-electron microscopy and modeling studies, emphasizing implications to chromatin organization and epigenetic regulation broadly.