Synthesis of functionalized hydroxymethylene-containing bisorganophosphorus acids

Abstract

Convenient syntheses of functionalized bisorganophosphorus acids and their derivatives containing hydroxymethylene moieties have been developed. Trimethylsilyl esters of trivalent phosphorus acids react with acyl chlorides to give new hydroxymethylene-substituted functionalized bisorganophosphorus acids containing P—C—P units. The resulting compounds are structural analogs of pharmaceutical agents used to treat various diseases. They are also of interest as promising biologically active substances and effective polydentate ligands.