Caroline M Lara, Toni Castro Torres, Usaid Mazhar, Dorrian G Cohen, Rebecca A Wingert
{"title":"The Hippo Pathway in Kidney Development.","authors":"Caroline M Lara, Toni Castro Torres, Usaid Mazhar, Dorrian G Cohen, Rebecca A Wingert","doi":"10.3390/encyclopedia5010015","DOIUrl":null,"url":null,"abstract":"<p><p>The kidney, a complex organ crucial for a multitude of homeostatic functions, including the maintenance of fluid and electrolyte balance, removal of various metabolic waste products, and hormone production, undergoes intricate developmental processes to form functional nephron units. Understanding the mechanisms behind kidney development is paramount for elucidating the etiology of renal congenital disabilities and acquired diseases. The Hippo pathway is known for its involvement in various cellular functions, including cell fate determination and differentiation, and is a critical player in renal organogenesis. Here, we discuss research findings about the roles that Hippo signaling plays in kidney formation.</p>","PeriodicalId":72905,"journal":{"name":"Encyclopedia","volume":"5 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12456234/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Encyclopedia","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3390/encyclopedia5010015","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/26 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
The kidney, a complex organ crucial for a multitude of homeostatic functions, including the maintenance of fluid and electrolyte balance, removal of various metabolic waste products, and hormone production, undergoes intricate developmental processes to form functional nephron units. Understanding the mechanisms behind kidney development is paramount for elucidating the etiology of renal congenital disabilities and acquired diseases. The Hippo pathway is known for its involvement in various cellular functions, including cell fate determination and differentiation, and is a critical player in renal organogenesis. Here, we discuss research findings about the roles that Hippo signaling plays in kidney formation.
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