Monika Pogány Simonová, Ľubica Chrastinová, Jana Ščerbová, Katarína Tokarčíková, Ľubomíra Grešáková, Rudolf Žitňan, Iveta Plachá, Andrea Lauková
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引用次数: 0
Abstract
Increasing occurrence of methicillin-resistant (MR) staphylococci in humans and animals leads to special attention because of their difficult treatment and zoonotic character. Therefore, novel natural antimicrobial compounds directed against antibiotic-resistant bacteria are requested to overcome this problem. Currently, bacteriocins/enterocins (proteinaceous substances with antimicrobial activity produced by several lactic acid bacteria/enterococci) present a new promising strategy, both in prevention and treatment. The aim of this work was to evaluate the effect of Enterocin Ent7420 against the MR Staphylococcus epidermidis SEP3/Tr2a (MRSE) strain in a rabbit (food animal) model, testing its influence and protective effect on body weight (BW), feed conversion ratio (FCR), phagocytic activity (PA), serum glutathione-peroxidase (GPx) enzyme activity, and jejunal morphology (JM). Ninety-six weaned broiler rabbits were divided into experimental groups S (MRSE strain; to simulate the pathogen attack), E (Ent7420), E + S (Ent7420 + MRSE), and control group (C; without substances). Higher BW and lower FCR (NS) were recorded during Ent7420 application. Decreased JM values (p < 0.05) reflect the MRSE strain's damaging effect on the rabbit organism. Improved parameters of GPx and JM during substance combination suggest that Ent7420 may mitigate staphylococcal pathogenesis, warranting further investigation. These results suggest not only promising preventive use of Ent7420 to improve the growth and immunity of rabbits but also its protective effect against possible staphylococcal (MRSE) infections in rabbit breeding.
期刊介绍：
Frontiers in Veterinary Science is a global, peer-reviewed, Open Access journal that bridges animal and human health, brings a comparative approach to medical and surgical challenges, and advances innovative biotechnology and therapy.
Veterinary research today is interdisciplinary, collaborative, and socially relevant, transforming how we understand and investigate animal health and disease. Fundamental research in emerging infectious diseases, predictive genomics, stem cell therapy, and translational modelling is grounded within the integrative social context of public and environmental health, wildlife conservation, novel biomarkers, societal well-being, and cutting-edge clinical practice and specialization. Frontiers in Veterinary Science brings a 21st-century approach—networked, collaborative, and Open Access—to communicate this progress and innovation to both the specialist and to the wider audience of readers in the field.
Frontiers in Veterinary Science publishes articles on outstanding discoveries across a wide spectrum of translational, foundational, and clinical research. The journal''s mission is to bring all relevant veterinary sciences together on a single platform with the goal of improving animal and human health.
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