¹⁸F-NaF PET/CT for early detection of osteoporosis in the lumbar spine: two case reports.

IF 1.8 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

American journal of nuclear medicine and molecular imaging Pub Date : 2025-08-15 eCollection Date: 2025-01-01 DOI:10.62347/IXKG9158

Shiv Patil, Nirmal Patel, Eric Teichner, William Lee, Ehsan Ranjbar, Alexander Gerlach, Robert Subtirelu, Lancelot Herpin, Thomas Werner, Poul Flemming Høilund-Carlsen, Abass Alavi

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Abstract

Osteoporosis is a highly prevalent skeletal disease involving a pathophysiology of altered bone turnover. Positron emission tomography (PET)/computed tomography (CT) imaging with ¹⁸F-sodium fluoride (NaF) can visualize metabolic alterations in bone that precede clinical manifestations or structural alterations and thus may serve a role in the early detection and monitoring of osteoporosis. We present two non-oncological case reports demonstrating different metabolic changes in early and advanced disease stages as assessed by ¹⁸F-NaF PET/CT that cannot be appreciated by conventional structural imaging alone, supporting a potential clinical application of ¹⁸F-NaF PET/CT for early detection and monitoring of osteoporosis in the lumbar spine.

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18F-NaF PET/CT早期发现腰椎骨质疏松症2例报告

骨质疏松症是一种非常普遍的骨骼疾病，涉及改变骨转换的病理生理。用18f氟化钠（NaF）进行正电子发射断层扫描(PET)/计算机断层扫描（CT）成像可以观察在临床表现或结构改变之前骨骼的代谢改变，因此可能在骨质疏松症的早期发现和监测中发挥作用。我们提出了两个非肿瘤学病例报告，通过18F-NaF PET/CT评估了疾病早期和晚期的不同代谢变化，而传统的结构成像无法单独评估这些变化，这支持了18F-NaF PET/CT在腰椎骨质疏松症早期检测和监测中的潜在临床应用。

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来源期刊

American journal of nuclear medicine and molecular imaging RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-

自引率

4.00%

发文量

期刊介绍： The scope of AJNMMI encompasses all areas of molecular imaging, including but not limited to: positron emission tomography (PET), single-photon emission computed tomography (SPECT), molecular magnetic resonance imaging, magnetic resonance spectroscopy, optical bioluminescence, optical fluorescence, targeted ultrasound, photoacoustic imaging, etc. AJNMMI welcomes original and review articles on both clinical investigation and preclinical research. Occasionally, special topic issues, short communications, editorials, and invited perspectives will also be published. Manuscripts, including figures and tables, must be original and not under consideration by another journal.