Novel tracers and emerging targets for positron emission tomography in Alzheimer's disease and related dementias.

IF 1.8 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

American journal of nuclear medicine and molecular imaging Pub Date : 2025-08-15 eCollection Date: 2025-01-01 DOI:10.62347/ERGQ2963

Taoqian Zhao, Steven H Liang

引用次数: 0

Abstract

This symposium provided an extensive overview of emerging positron emission tomography (PET) tracers and targets for Alzheimer's disease (AD) and related dementias (ADRD), highlighting novel approaches for imaging neuroinflammation, neurotransmitter systems, mitochondrial dysfunction, and proteinopathies. Key developments included the harmonization of PET data across cohorts, new tau and alpha-synuclein tracers, and critical advancements in understanding neurodegenerative disease heterogeneity through integrated imaging, genetic, and pathological studies.

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阿尔茨海默病和相关痴呆的正电子发射断层扫描的新型示踪剂和新靶点。

本次研讨会广泛概述了新出现的正电子发射断层扫描（PET）示踪剂和阿尔茨海默病（AD）和相关痴呆（ADRD）的靶点，重点介绍了神经炎症、神经递质系统、线粒体功能障碍和蛋白质病变成像的新方法。关键进展包括跨队列PET数据的统一，新的tau和α -突触核蛋白示踪剂，以及通过综合成像、遗传和病理研究在理解神经退行性疾病异质性方面的关键进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American journal of nuclear medicine and molecular imaging RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-

自引率

4.00%

发文量

期刊介绍： The scope of AJNMMI encompasses all areas of molecular imaging, including but not limited to: positron emission tomography (PET), single-photon emission computed tomography (SPECT), molecular magnetic resonance imaging, magnetic resonance spectroscopy, optical bioluminescence, optical fluorescence, targeted ultrasound, photoacoustic imaging, etc. AJNMMI welcomes original and review articles on both clinical investigation and preclinical research. Occasionally, special topic issues, short communications, editorials, and invited perspectives will also be published. Manuscripts, including figures and tables, must be original and not under consideration by another journal.