Vascular and tissue effects of photodynamic therapy in a murine cutaneous tumor model

IF 3.7 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of photochemistry and photobiology. B, Biology Pub Date : 2025-09-17 DOI:10.1016/j.jphotobiol.2025.113269

Mirian Denise Stringasci , Michelle Barreto Requena , Clara Maria Gonçalves de Faria , Fernando Silva Ramalho , Vanderlei Salvador Bagnato

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引用次数: 0

Abstract

Skin cancer is the most common neoplasm worldwide and presents a significant health concern. Topical photodynamic therapy (PDT) has emerged as a therapeutic option for treating malignant and potentially precancerous skin lesions. To improve this technique and design more effective protocols, it is vital to understand the relationship between PDT damage in blood vessels and surrounding tissues. In this study, solid tumors of squamous cell carcinoma (SCC) were induced in balb/c nude mice. Damages were evaluated using histology and optical coherence tomography (OCT) images to compare PDT protocols using systemic and topical photosensitizer (PS) administration with different irradiances. The results are promising and may support the development of new and more effective PDT protocols for clinical treatment, including those that require multiple treatment sessions.

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光动力疗法对小鼠皮肤肿瘤模型血管和组织的影响

皮肤癌是世界上最常见的肿瘤，是一个重要的健康问题。局部光动力疗法（PDT）已成为治疗恶性和潜在癌前皮肤病变的一种治疗选择。为了改进这项技术并设计更有效的方案，了解血管和周围组织的PDT损伤之间的关系至关重要。本研究在balb/c裸鼠身上诱导鳞状细胞癌（SCC）实体瘤。使用组织学和光学相干断层扫描（OCT）图像对损伤进行评估，以比较使用不同辐照度的全身光敏剂和局部光敏剂（PS）的PDT方案。研究结果是有希望的，并可能支持开发新的和更有效的PDT临床治疗方案，包括那些需要多次治疗的方案。

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来源期刊

Journal of photochemistry and photobiology. B, Biology 生物-生化与分子生物学

CiteScore

12.10

自引率

1.90%

发文量

161

审稿时长

37 days

期刊介绍： The Journal of Photochemistry and Photobiology B: Biology provides a forum for the publication of papers relating to the various aspects of photobiology, as well as a means for communication in this multidisciplinary field. The scope includes: - Bioluminescence - Chronobiology - DNA repair - Environmental photobiology - Nanotechnology in photobiology - Photocarcinogenesis - Photochemistry of biomolecules - Photodynamic therapy - Photomedicine - Photomorphogenesis - Photomovement - Photoreception - Photosensitization - Photosynthesis - Phototechnology - Spectroscopy of biological systems - UV and visible radiation effects and vision.