The research progress of α-ketoglutarate in osteoarthritis

IF 2.2 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochemistry and Biophysics Reports Pub Date : 2025-09-18 DOI:10.1016/j.bbrep.2025.102270

Fanghao Long , Junlin Xiang , Yangfan Tan, Jun Zhao, Chi Ma

引用次数: 0

Abstract

α-Ketoglutarate (AKG) is a key intermediate in the tricarboxylic acid, (TCA) cycle. AKG is not only involved in cellular energy metabolism but also plays important roles in a variety of physiological and pathological processes such as antioxidant activity, anti-inflammatory effects, immune regulation, and maintenance of mitochondrial function, which have garnered widespread attention. Many experiments have shown that there is a certain correlation between AKG and OA. The purpose of this paper is to comprehensively review the literature to elucidate the mechanisms of AKG in alleviating osteoarthritis (OA), such as autophagy, gut microbiota, cellular senescence, and ferroptosis. We aim to provide theoretical references and evidence for the use of AKG in the prevention and treatment of OA.

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α-酮戊二酸酯在骨关节炎中的研究进展

α-酮戊二酸酯（AKG）是三羧酸（TCA）循环的关键中间体。AKG不仅参与细胞能量代谢，还在抗氧化、抗炎、免疫调节、线粒体功能维持等多种生理病理过程中发挥重要作用，受到广泛关注。许多实验表明AKG与OA之间存在一定的相关性。本文旨在综合文献，从自噬、肠道菌群、细胞衰老、铁下垂等方面阐述AKG减轻骨关节炎（OA）的作用机制。我们旨在为AKG在OA预防和治疗中的应用提供理论参考和证据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biochemistry and Biophysics Reports Biochemistry, Genetics and Molecular Biology-Biophysics

CiteScore

4.60

自引率

0.00%

发文量

191

审稿时长

59 days

期刊介绍： Open access, online only, peer-reviewed international journal in the Life Sciences, established in 2014 Biochemistry and Biophysics Reports (BB Reports) publishes original research in all aspects of Biochemistry, Biophysics and related areas like Molecular and Cell Biology. BB Reports welcomes solid though more preliminary, descriptive and small scale results if they have the potential to stimulate and/or contribute to future research, leading to new insights or hypothesis. Primary criteria for acceptance is that the work is original, scientifically and technically sound and provides valuable knowledge to life sciences research. We strongly believe all results deserve to be published and documented for the advancement of science. BB Reports specifically appreciates receiving reports on: Negative results, Replication studies, Reanalysis of previous datasets.