Mn(III)-mediated defluorinative radical cyclization of β,β-difluoro-ortho-alkenyl isocyanides with boronic acids: Access to 3-fluoroquinoline derivatives

IF 2.2 3区化学 Q2 CHEMISTRY, ORGANIC

Tetrahedron Pub Date : 2025-09-13 DOI:10.1016/j.tet.2025.134942

Yanfeng Zhou , Lei Ma

引用次数: 0

Abstract

A Mn(III)-mediated cascade synthesis of 3-fluoroquinoline derivatives through radical cyclization of β,β-difluoro-ortho-alkenyl isocyanides with boronic acids is reported. This strategy features high efficiency, broad substrate scope and good functional group tolerance. The scalability of the process is demonstrated with gram-scale reactions yielding promising results, highlighting its practical applicability.

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锰（III）介导β，β-二氟邻烯基异氰酸酯与硼酸的去氟自由基环化：获得3-氟喹啉衍生物

报道了锰（III）介导的β，β-二氟邻烯基异氰酸酯与硼酸自由基环化合成3-氟喹啉衍生物。该策略具有效率高、基板范围广、官能团容忍度好等特点。通过克级反应证明了该工艺的可扩展性，产生了有希望的结果，突出了其实用性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Tetrahedron 化学-有机化学

CiteScore

3.90

自引率

4.80%

发文量

439

审稿时长

34 days

期刊介绍： Tetrahedron publishes full accounts of research having outstanding significance in the broad field of organic chemistry and its related disciplines, such as organic materials and bio-organic chemistry. Regular papers in Tetrahedron are expected to represent detailed accounts of an original study having substantially greater scope and details than that found in a communication, as published in Tetrahedron Letters. Tetrahedron also publishes thematic collections of papers as special issues and ''Reports'', commissioned in-depth reviews providing a comprehensive overview of a research area.