Isosulochrin xanthone and isosulochrin depsidone heterodimers from the endophytic fungus Colletotrichum sp. NF02092

IF 1.5 4区化学 Q3 CHEMISTRY, ORGANIC

Tetrahedron Letters Pub Date : 2025-09-18 DOI:10.1016/j.tetlet.2025.155832

Xing Guo , Yang Zhao , Yan Wang, Huiming Ge, Bo Zhang

引用次数: 0

Abstract

In this study, we isolated and characterized two polyketides (1 and 2), along with reported depsidone derivative (3) from fermentation broth of the marine fish-derived endophytic fungus Colletotrichum sp. NF02092. The structures of 1 and 2 were deduced on the basis of comprehensive analysis of HRESIMS and NMR spectroscopic data. Both compounds are heterodimers formed by the fusion of the core structure isosulochrin with a xanthan (1) and a depsidone (2), respectively. However, neither 1 nor 2 exhibited significant antimicrobial activity or cytotoxic activities.

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内生真菌Colletotrichum sp. NF02092的异桃金酮山酮和异桃金酮异二聚体

在这项研究中，我们从海洋鱼类来源的内生真菌Colletotrichum sp. NF02092的发酵液中分离并鉴定了两种聚酮（1和2）以及报道的depsidone衍生物(3)。在综合分析hremsims和NMR数据的基础上，推导出了1和2的结构。这两种化合物都是异质二聚体，分别由核心结构异氯草苷与黄原胶(1)和depsidone(2)融合而成。然而，1和2都没有表现出显著的抗菌活性或细胞毒活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Tetrahedron Letters 化学-有机化学

CiteScore

3.50

自引率

5.60%

发文量

521

审稿时长

28 days

期刊介绍： Tetrahedron Letters provides maximum dissemination of outstanding developments in organic chemistry. The journal is published weekly and covers developments in techniques, structures, methods and conclusions in experimental and theoretical organic chemistry. Rapid publication of timely and significant research results enables researchers from all over the world to transmit quickly their new contributions to large, international audiences.