GBP1-CDK9-STAT3 signaling axis promotes osteosarcoma PD-L1 expression and immune escape

IF 7.7 2区 医学 Q1 Biochemistry, Genetics and Molecular Biology
Doudou Jing , Binghong Chen , Ruqi Liang , Fei Li , Bin Zhao , Feifei Pu , Wei Wu
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引用次数: 0

Abstract

Osteosarcoma is a common malignant bone tumor, characterized by its high invasiveness and propensity for lung metastasis. Despite advances in treatment, clinical outcomes remain poor, and patient prognosis is still unsatisfactory. Therefore, the development of more effective therapies is urgently needed. Here, we demonstrate that differential expression of GBP1 significantly influences PD-L1 expression and mediates immune escape in osteosarcoma. Specifically, our results reveal that GBP1 regulates PD-L1 expression by activating CDK9 and promoting STAT3 phosphorylation. These findings suggest that targeting GBP1 may represent a promising therapeutic strategy for the treatment of osteosarcoma by impairing tumor immune evasion.
GBP1-CDK9-STAT3信号轴促进骨肉瘤PD-L1表达和免疫逃逸
骨肉瘤是一种常见的骨恶性肿瘤,具有高侵袭性和肺转移倾向。尽管在治疗方面取得了进展,但临床结果仍然很差,患者预后仍然令人不满意。因此,迫切需要开发更有效的治疗方法。本研究表明,GBP1的差异表达显著影响骨肉瘤中PD-L1的表达并介导免疫逃逸。具体来说,我们的研究结果表明GBP1通过激活CDK9和促进STAT3磷酸化来调节PD-L1的表达。这些发现表明,靶向GBP1可能是一种很有前途的治疗策略,可以通过破坏肿瘤免疫逃避来治疗骨肉瘤。
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来源期刊
Neoplasia
Neoplasia 医学-肿瘤学
CiteScore
9.20
自引率
2.10%
发文量
82
审稿时长
26 days
期刊介绍: Neoplasia publishes the results of novel investigations in all areas of oncology research. The title Neoplasia was chosen to convey the journal’s breadth, which encompasses the traditional disciplines of cancer research as well as emerging fields and interdisciplinary investigations. Neoplasia is interested in studies describing new molecular and genetic findings relating to the neoplastic phenotype and in laboratory and clinical studies demonstrating creative applications of advances in the basic sciences to risk assessment, prognostic indications, detection, diagnosis, and treatment. In addition to regular Research Reports, Neoplasia also publishes Reviews and Meeting Reports. Neoplasia is committed to ensuring a thorough, fair, and rapid review and publication schedule to further its mission of serving both the scientific and clinical communities by disseminating important data and ideas in cancer research.
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