Cumulative Effect of Hyperglycemia and Insulin Resistance on Cardiac Dysfunction - TheCoronary Artery Risk Development in Young Adults (CARDIA) Study.

IF 3.5 2区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

American heart journal Pub Date : 2025-09-17 DOI:10.1016/j.ahj.2025.09.008

Yilin Yoshida, Yuanhao Zu, David Aguilar, Keith C Ferdinand, Vivian A Fonseca

引用次数: 0

Abstract

We investigated whether cumulative fasting glucose (FG) and insulin resistance (IR) over 20 years are associated with midlife cardiac dysfunction in young adults with or without type 2 diabetes (T2D)/pre-diabetes. We included young adults with T2D/prediabetes (N=279) and matched euglycemic individuals (N=514) who had repeated measures of FG and IR and echocardiography assessment from the Coronary Artery Risk Development in Young Adults study (CARDIA). We found that cumulative hyperglycemia is associated with midlife diastolic dysfunction in patients with early-onset T2D, and sustained IR negatively affects systolic and diastolic function regardless of T2D status.

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高血糖和胰岛素抵抗对心功能障碍的累积影响——青年人冠状动脉风险发展（CARDIA）研究。

我们研究了20年的累积空腹血糖（FG）和胰岛素抵抗（IR）是否与伴有或不伴有2型糖尿病(T2D)/前驱糖尿病的年轻人中年心功能障碍相关。我们纳入了T2D/糖尿病前期的年轻成人（N=279）和匹配的血糖正常的个体（N=514），他们重复测量了青年人冠状动脉风险发展研究（CARDIA）中的FG和IR以及超声心动图评估。我们发现，早发性T2D患者的累积性高血糖与中年舒张功能障碍相关，持续IR对收缩和舒张功能有负面影响，与T2D状态无关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American heart journal 医学-心血管系统

CiteScore

8.20

自引率

2.10%

发文量

214

审稿时长

38 days

期刊介绍： The American Heart Journal will consider for publication suitable articles on topics pertaining to the broad discipline of cardiovascular disease. Our goal is to provide the reader primary investigation, scholarly review, and opinion concerning the practice of cardiovascular medicine. We especially encourage submission of 3 types of reports that are not frequently seen in cardiovascular journals: negative clinical studies, reports on study designs, and studies involving the organization of medical care. The Journal does not accept individual case reports or original articles involving bench laboratory or animal research.