Synthesis of N-acyl-homoserine lactones analogs for improving the potential application of Acidithiobacillus thiooxidans in bioleaching

IF 2.6 3区生物学 Q3 MICROBIOLOGY

Archives of Microbiology Pub Date : 2025-09-20 DOI:10.1007/s00203-025-04473-2

Deping Tang, Mengjiao Li, Wentao Song, Yanpeng Xi, Yali Liu, Yanyan Lin, Hao Feng, Aihong Mao

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Abstract

Quorum-sensing agonists significantly enhance biofilm formation and bioleaching efficiency. In this study, we synthesized acyl-homoserine lactone (AHL) analogs and investigated their effects on biofilm formation in Acidithiobacillus thiooxidans, mineral adsorption kinetics, and pentlandite bioleaching. The results showed that A-3 promoted biofilm formation, enhanced adsorption capacity toward pentlandite, and improved pentlandite bioleaching efficiency. Molecular docking revealed that A-3 exhibited higher binding affinity for the quorum-sensing receptor protein AfeR than its natural signaling ligand. In summary, compared to the natural signaling molecule, A-3 significantly enhanced biofilm formation and adsorption capacity, consequently improving bioleaching efficiency. This establishes a theoretical foundation for optimizing bioleaching in industrial applications.

Graphical abstract

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n -酰基同丝氨酸内酯类似物的合成以提高酸性硫氧化硫杆菌在生物浸出中的应用潜力

群体感应激动剂显著提高生物膜的形成和生物浸出效率。在这项研究中，我们合成了酰基-高丝氨酸内酯（AHL）类似物，并研究了它们对酸性硫氧化硫杆菌生物膜形成、矿物吸附动力学和镍黄铁矿生物浸出的影响。结果表明，A-3促进了生物膜的形成，增强了对镍黄铁矿的吸附能力，提高了镍黄铁矿的生物浸出效率。分子对接表明，A-3对群体感应受体蛋白AfeR的结合亲和力高于其天然信号配体。综上所述，与天然信号分子相比，A-3显著增强了生物膜的形成和吸附能力，从而提高了生物浸出效率。这为优化工业应用中的生物浸出奠定了理论基础。图形抽象

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来源期刊

Archives of Microbiology 生物-微生物学

CiteScore

4.90

自引率

3.60%

发文量

601

审稿时长

3 months

期刊介绍： Research papers must make a significant and original contribution to microbiology and be of interest to a broad readership. The results of any experimental approach that meets these objectives are welcome, particularly biochemical, molecular genetic, physiological, and/or physical investigations into microbial cells and their interactions with their environments, including their eukaryotic hosts. Mini-reviews in areas of special topical interest and papers on medical microbiology, ecology and systematics, including description of novel taxa, are also published. Theoretical papers and those that report on the analysis or ''mining'' of data are acceptable in principle if new information, interpretations, or hypotheses emerge.