Concurrent Ferroptosis and Pyroptosis Induced by a Dual-Organelle-Targeted Type I/II AIE Photosensitizer for Bladder Cancer Immunotherapy

IF 16.9 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Angewandte Chemie International Edition Pub Date : 2025-09-18 DOI:10.1002/anie.202509783

Yifan Cheng, Kun Zhou, Yuhang Chen, Yibo Mei, Zhongyu Wang, Wen-Jin Wang, Haowen Li, Yixuan Chen, Zonghang Liu, Jin Zeng, Yumei Luo, Dalin He, Zheng Zhao, Ben Zhong Tang

引用次数: 0

Abstract

We report a dual-targeting aggregation-induced emission photosensitizer (AIE PS) that specifically accumulates in endoplasmic reticulum (ER) and lipid droplets (LDs). Upon irradiation, it produces multiple reactive oxygen species (ROS), inducing organelle disruption, lipid peroxidation, and concurrent ferroptosis and pyroptosis, ultimately activating potent anti-tumor immunity.

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双细胞器靶向I/II型AIE光敏剂诱导膀胱癌免疫治疗并发铁下垂和焦下垂

我们报道了一种双靶向聚集诱导发射光敏剂（AIE PS），它特异性地积聚在内质网（ER）和脂滴（ld）中。辐照后，它产生多种活性氧（ROS），诱导细胞器破坏、脂质过氧化和同时发生铁下垂和焦下垂，最终激活有效的抗肿瘤免疫。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Angewandte Chemie International Edition 化学-化学综合

CiteScore

26.60

自引率

6.60%

发文量

3549

审稿时长

1.5 months

期刊介绍： Angewandte Chemie, a journal of the German Chemical Society (GDCh), maintains a leading position among scholarly journals in general chemistry with an impressive Impact Factor of 16.6 (2022 Journal Citation Reports, Clarivate, 2023). Published weekly in a reader-friendly format, it features new articles almost every day. Established in 1887, Angewandte Chemie is a prominent chemistry journal, offering a dynamic blend of Review-type articles, Highlights, Communications, and Research Articles on a weekly basis, making it unique in the field.