The Spectrum of Malignant Diagnoses in Cerebrospinal Fluid (CSF) Cytology in Both Pediatric and Adult Populations: A Single-Institutional Retrospective Review.

IF 1 4区 医学 Q4 MEDICAL LABORATORY TECHNOLOGY
Nida Babar, Asif Loya, Sajid Mushtaq, Maryam Hameed, Usman Hassan, Mudassar Hussain
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引用次数: 0

Abstract

Introduction: Positive cerebrospinal fluid (CSF) cytology remains a cornerstone and irreplaceable diagnostic modality for the indication of leptomeningeal dissemination by primary as well as metastatic malignancies. Identification of tumor cells is fundamental for institution of aggressive treatment, such as radiotherapy, intrathecal chemotherapy, or systemic therapies, and will help increase overall survival. We did a retrospective analysis of CSF cytology in our center of all samples diagnosed as positive for malignant cells from January 2001 to December 2024 to find out about the spectrum of malignancies being detected in CSF cytology.

Methods: We searched the database of our Hospital from January 2001 to December 2024 and found 853 samples of CSF of different patients that were diagnosed as positive for malignant cells. All cases were reviewed independently by two cytopathologists, and no discrepancy was found.

Results: The diagnostic spectrum included cases of metastatic solid and hematolymphoid malignancies as well as dissemination of primary CNS tumors to CSF. Out of 853 cases, 550 cases were of CSF involvement by blast cells, 132 were of metastatic carcinomas, 78 were of hematological malignancies other than lymphoblastic lymphomas, 82 were of primary CNS tumors involving CSF, and 11 were of various other malignancies, including a spectrum of round blue cell tumors and sarcomas.

Conclusions: A broad spectrum of epithelial, mesenchymal, and hematolymphoid malignancies can be diagnosed on CSF cytology, and these are likely metastatic in origin. Hematolymphoid malignancies, especially lymphoblastic lymphoma in children, are most common. Likewise, metastatic carcinomas constitute the major bulk of the adult population.

儿童和成人人群脑脊液(CSF)细胞学恶性诊断谱:一项单机构回顾性评价。
脑脊液(CSF)细胞学阳性仍然是原发性和转移性恶性肿瘤的脑脊液播散指征的基础和不可替代的诊断方式。肿瘤细胞的识别是积极治疗的基础,如放疗、鞘内化疗或全身治疗,并有助于提高总生存率。我们对本中心2001年1月至2024年12月诊断为恶性细胞阳性的所有样本进行了脑脊液细胞学回顾性分析,以了解脑脊液细胞学中检测到的恶性肿瘤的谱。方法:检索我院2001年1月至2024年12月的数据库,发现853例不同患者的脑脊液标本均为恶性肿瘤细胞阳性。所有病例均由两名细胞病理学家独立复查,未发现差异。结果:诊断谱包括转移性实体和血淋巴恶性肿瘤,以及原发性中枢神经系统肿瘤向脑脊液的播散。在853例病例中,550例为胚细胞累及脑脊液,132例为转移性癌,78例为淋巴母细胞淋巴瘤以外的血液学恶性肿瘤,82例为原发性中枢神经系统肿瘤累及脑脊液,11例为各种其他恶性肿瘤,包括圆形蓝细胞瘤和肉瘤。结论:脑脊液细胞学可以诊断广泛的上皮、间充质和淋巴细胞恶性肿瘤,这些肿瘤可能是转移性的。血液淋巴类恶性肿瘤,尤其是儿童淋巴母细胞淋巴瘤是最常见的。同样,转移性癌构成了成年人的主要部分。
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来源期刊
Diagnostic Cytopathology
Diagnostic Cytopathology 医学-病理学
CiteScore
2.60
自引率
7.70%
发文量
163
审稿时长
3-6 weeks
期刊介绍: Diagnostic Cytopathology is intended to provide a forum for the exchange of information in the field of cytopathology, with special emphasis on the practical, clinical aspects of the discipline. The editors invite original scientific articles, as well as special review articles, feature articles, and letters to the editor, from laboratory professionals engaged in the practice of cytopathology. Manuscripts are accepted for publication on the basis of scientific merit, practical significance, and suitability for publication in a journal dedicated to this discipline. Original articles can be considered only with the understanding that they have never been published before and that they have not been submitted for simultaneous review to another publication.
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