{"title":"Challenges and Pitfalls to Diagnosing NUTM1-Rearranged Neoplasia of the Pancreas by Cytology and Ancillary Studies.","authors":"Terrance J Lynn","doi":"10.1002/dc.70021","DOIUrl":null,"url":null,"abstract":"<p><p>Fine-needle aspiration cytology specimens are frequently utilized for ancillary studies to identify diagnostic and prognostic information. This case highlights diagnostic pitfalls and challenges in diagnosing NUTM1-rearranged neoplasia on pancreatic cytology. NUT carcinomas and sarcomas have highly variable cytomorphology, immunohistochemical staining profiles, and various gene partners involved in the fusion. Detecting these clinically relevant gene fusions in cytologic specimens can be particularly challenging as new diagnostic entities emerge. In cytologic specimens with a wide differential, maximizing the tissue for ancillary studies and selecting appropriate studies are critical. Finally, it highlights the importance of molecular cytopathology for patient care in complex and rare fusion-driven entities and the need for orthogonal testing when results are discordant and unexpected.</p>","PeriodicalId":11349,"journal":{"name":"Diagnostic Cytopathology","volume":" ","pages":""},"PeriodicalIF":1.0000,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Diagnostic Cytopathology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/dc.70021","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MEDICAL LABORATORY TECHNOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Fine-needle aspiration cytology specimens are frequently utilized for ancillary studies to identify diagnostic and prognostic information. This case highlights diagnostic pitfalls and challenges in diagnosing NUTM1-rearranged neoplasia on pancreatic cytology. NUT carcinomas and sarcomas have highly variable cytomorphology, immunohistochemical staining profiles, and various gene partners involved in the fusion. Detecting these clinically relevant gene fusions in cytologic specimens can be particularly challenging as new diagnostic entities emerge. In cytologic specimens with a wide differential, maximizing the tissue for ancillary studies and selecting appropriate studies are critical. Finally, it highlights the importance of molecular cytopathology for patient care in complex and rare fusion-driven entities and the need for orthogonal testing when results are discordant and unexpected.
期刊介绍：
Diagnostic Cytopathology is intended to provide a forum for the exchange of information in the field of cytopathology, with special emphasis on the practical, clinical aspects of the discipline. The editors invite original scientific articles, as well as special review articles, feature articles, and letters to the editor, from laboratory professionals engaged in the practice of cytopathology. Manuscripts are accepted for publication on the basis of scientific merit, practical significance, and suitability for publication in a journal dedicated to this discipline. Original articles can be considered only with the understanding that they have never been published before and that they have not been submitted for simultaneous review to another publication.
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