Mesenchymal Stem Cell Senescence and Biomaterial-Based Next-Generation Rejuvenation Strategy.

IF 4.6 2区医学 Q2 CELL & TISSUE ENGINEERING

Tissue Engineering. Part B, Reviews Pub Date : 2025-09-15 DOI:10.1177/19373341251372962

Yiran Zhang, Rana Judeh, Sidharth Aravind, Hala Zreiqat, Zufu Lu

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引用次数: 0

Abstract

The capacity for tissue regeneration declines with age, and cellular senescence is recognized as a critical driver of aging and impaired tissue regeneration potential. Advances in stem cell research have provided new insights into tissue regeneration and stem cell therapy in aging-related diseases. However, stem cell senescence significantly limits their therapeutic efficacy, highlighting the need for effective rejuvenation strategies. Current antisenescence approaches have shown promise, but they still face limitations. This review summarizes and discusses the characteristics and consequences of mesenchymal stem cells (MSCs) senescence and evaluates existing antisenescence strategies. Additionally, recent advancements in biomaterials have demonstrated considerable potential in modulating stem cell fate and enhancing tissue regeneration outcomes. In this context, we explore biomaterial-based approaches for rejuvenating senescent MSCs, offering novel perspectives for advancing tissue regeneration therapies targeting aging-related diseases.

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间充质干细胞衰老和基于生物材料的下一代年轻化策略。

组织再生能力随着年龄的增长而下降，细胞衰老被认为是衰老和组织再生潜力受损的关键驱动因素。干细胞研究的进展为组织再生和干细胞治疗衰老相关疾病提供了新的见解。然而，干细胞衰老显著地限制了它们的治疗效果，强调了有效的年轻化策略的需要。目前的抗衰老方法已经显示出希望，但它们仍然面临局限性。本文综述并讨论了间充质干细胞（MSCs）衰老的特征和后果，并评估了现有的抗衰老策略。此外，最近生物材料的进步已经证明了在调节干细胞命运和增强组织再生结果方面具有相当大的潜力。在此背景下，我们探索了基于生物材料的方法来恢复衰老的间充质干细胞，为推进针对衰老相关疾病的组织再生治疗提供了新的视角。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Tissue Engineering. Part B, Reviews Biochemistry, Genetics and Molecular Biology-Biochemistry

CiteScore

12.80

自引率

1.60%

发文量

150

期刊介绍： Tissue Engineering Reviews (Part B) meets the urgent need for high-quality review articles by presenting critical literature overviews and systematic summaries of research within the field to assess the current standing and future directions within relevant areas and technologies. Part B publishes bi-monthly.