Biosynthesis of sydonol reveals a new bisabolene cyclase and an unusual P450 aromatase.

IF 3.1 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Peiyu Lu, Ling Liu
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引用次数: 0

Abstract

In this work, the biosynthetic gene cluster and assembly line of sydonol were discovered and identified. As a result, and importantly, two unusual chemical conversions catalyzed by a new bisabolene cyclase and an unusual P450 aromatase were revealed: (1) cyclization of FPP to form 2, which involves a unique 1,5-proton transfer and a 1,7-hydride shift; and (2) aromatization of a bisabolene skeleton in the synthesis of 7.

糖醇的生物合成揭示了一个新的双abolene环化酶和一个不寻常的P450芳香化酶。
本研究发现并鉴定了sydonol的生物合成基因簇和组装线。结果,重要的是,揭示了由新的双abolene环化酶和不寻常的P450芳香化酶催化的两种不同寻常的化学转化:(1)FPP环化形成2,这涉及独特的1,5质子转移和1,7氢化物移位;(2)合成双abolene骨架的芳构化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
6.10
自引率
0.00%
发文量
128
审稿时长
10 weeks
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